It is an image that has stuck in the nation's mind; thick globules of white fat dripping off the end of a cigarette. Within days of the shocking image appearing on billboards and television, attendance at smoking clinics had doubled.

Now the group behind the advert is rolling out Part Two. The British Heart Foundation will today launch its 'Under My Skin' campaign, which will focus on what happens when the build-up of fatty deposits in the arteries rupture to form a blood clot.

It features images of a dark mass pulsing through a smoker's veins. The TV advert moves from the hand of a young woman in a fashionable bar to the neck of a suited man in a train station, ending with a close-up of a clot working its way towards the heart of a chef on a cigarette break. It runs under Frank Sinatra's version of 'I've Got You Under My Skin' and ends with the words 'A blood clot kills a smoker every 35 minutes' flashing on to the screen.

The £4 million campaign is designed to instill fear rather than disgust, says Professor Andrew Steptoe, the BHF's head of psychology. 'When it comes to smoking, most people are at the "tipping point"', he said. 'They know they shouldn't, but find it difficult to make the decision to stop at this moment. Like the previous campaign, these adverts were developed to tip smokers over the edge.'

The campaign will form part of a wider plan to curb smoking to be unveiled by Patricia Hewitt, the Health Secretary, this week.

Cabinet ministers will meet tomorrow to decide whether plans for a limited ban on smoking only in pubs that serve food should be replaced by an outright ban on smoking in all pubs and restaurants, or by a compromise that would allow pubs to set aside rooms for smokers. The decision is expected to be outlined in a white paper to be published on Wednesday.

The Department of Health approached the BHF to devise another anti-smoking campaign after the success of the previous award-winning ads, which led to 30,000 hits on its website to find out how to quit and thousands giving up.

That advert spurred Katy Leggate, 25, to give up after 13 years. 'It was horrible and disgusting,' she said. 'I never realised that was what was happening to my arteries. I saw [an ad] the evening before I quit and I think that gave me the extra kick that I needed to quit and stay quit.'

The government has set the same targets for today's campaign, which will see 2,200 billboards go up across the country. It is aimed at smokers aged between 30 and 50 who have tried repeatedly to give up.

The more subtle campaign uses the Cole Porter song because of its appropriate lyrics that include: 'I've got you under my skin, I've got you deep in the heart of me ... I've tried so not to give in ... I'd sacrifice anything come what might, for the sake of having you near. In spite of a warning voice that comes in the night, and repeats, repeats in my ear.'

'We expect this one to have a slower burn,' said Betty McBride, policy and communications director at the BHF. 'But, thanks to Sinatra, every time they hear that song the smoker will bring to mind the unseen damage.'

Professor Peter Weissberg, medical director at the BHF, said smokers were significantly more likely to have the 'furring of the arteries' caused by the build-up of fat and more likely to have blood clots. If that occurred in the heart, it would cause a heart attack, he said; if it happened in the brain, it would prompt a stroke. Every 35 minutes, a smoker dies needlessly from a heart attack when a blood clot blocks a coronary artery.'

The launch comes as the BHF revealed that more than half of Britain's 12 million smokers mistakenly believe it is nicotine that causes heart disease, rather than tobacco smoke. The new campaign will aim to get across the link between smoking and heart disease, and persuade smokers to use government cessation clinics and nicotine replacement patches.

'Today's survey is worrying, because it suggests smokers think nicotine is the killer but it's the other constituents that damage arteries,' added Weissberg.

'Nicotine replacement therapy is an ideal way to give up smoking, because it satisfies the craving without causing the damage.'