1. 412BC Contributed, according to some, to the fall of Athens
2. 1173-4 First outbreak recorded in detail
3. 1580 90% of population of North America infected
4. 1729-30 Relatively few deaths, mainly among the elderly and pregnant
5. 1781-2 Tens of millions infected
6. 1830-1 Thousands dead, mostly elderly
7. 1833-4 Thousands dead, mostly elderly
8. 1878 "Fowl plague", probably avian flu
9. 1889-90 Asiatic flu, 1 million dead
10. 1918-20 Spanish flu, H1N1, 40m dead
11. 1957-8 Asian flu, H2N2, 2m dead
12. 1968-69 Hong Kong flu, H3N2, 1m dead
13. 1976 Swine flu (scare)
14. 1977 Russian flu (scare)
15. 1997-?? H5N1