Bred in the genes

Review: Blood Matters: A Journey Along the Genetic Frontier by Masha GessenHilary Rose finds hope and caution in a thoughtful survey of DNA-based medicine

From the edge

Review: Aids Sutra: Untold Stories from India, edited by Negar AkhaviAnita Sethi is moved to hear the voices of those afflicted by a modern scourge

‘Plain old untrendy troubles and emotions’

David Foster Wallace, who died last week, was the most brilliant American writer of his generation. In a speech, published here for the first time, he reflects on the difficulties of daily life and 'making it to 30, or maybe 50, without wanting to shoot yourself in the head'

Escape from self-help hell

Review: Self-help books roundupSupposedly enlightened writers are queueing up to tell us how to live our lives and earning a fortune in the process. Reader beware ... says Stephanie Merritt

Battle of the boatmen

Review: The Last Amateurs by Mark de RondDaniel Topolski relives the intense pressure of the varsity race that strives for Olympian levels